Positively charged patches: tonic for CAR fitness

Structural schematic CD70 targeting CAR T-cells for metastatic renal

Volume 33 Issue 5, May 2023

Engineering Self-Assembling Protein Nanoparticles for Therapeutic Delivery

Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness

The persistence and antitumor efficacy of CAR-T cells are modulated by tonic signaling within the CDR - ScienceDirect

Lym-1 and huLym-1-B CAR T cells with BB3z signaling domains are

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huLym-1-B-DAP CAR T cells mediate superior antitumor efficacy than BB3z

Example protein-sol visualisation of surface patches on a Fab. In (A)